Alpha-1 Antitrypsin Deficiency Phenotype and Lung Risk

Classify alpha-1 antitrypsin (SERPINA1) phenotype/genotype (PiZZ, PiSZ, PiMZ, PiSS) and estimate cumulative COPD, liver disease, and bronchiectasis risk based on smoking history and serum A1AT level.

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Clinical Guidance

BMI is a screening measure of body size, not a direct measure of body fat. The standard WHO categories are underweight (<18.5), normal (18.5–24.9), overweight (25–29.9), and obese (≥30).

BMI can overestimate body fat in athletes with high muscle mass and underestimate it in older adults with low muscle mass. Interpret it alongside waist circumference and clinical context rather than as a standalone diagnosis.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.
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How It Works

Classify alpha-1 antitrypsin (SERPINA1) phenotype/genotype (PiZZ, PiSZ, PiMZ, PiSS) and estimate cumulative COPD, liver disease, and bronchiectasis risk based on smoking history and serum A1AT level

Each component has a specific meaning:

  • Smoking history — The smoking history recorded for the scenario being assessed.
  • Serum A1AT level — The serum a1at level recorded for the scenario being assessed.

Note: Interpret the a1at deficiency risk result against the thresholds and context described above.

How to Use

Enter the smoking history, serum A1AT level for the scenario you are assessing. Classify alpha-1 antitrypsin (SERPINA1) phenotype/genotype (PiZZ, PiSZ, PiMZ, PiSS) and estimate cumulative COPD, liver disease, and bronchiectasis risk based on smoking history and serum A1AT level. Use the a1at deficiency risk result to inform your calculation.

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