What amikacin peak target is used for once-daily dosing?

Target peak of 56–64 mg/L (or minimum 8× MIC) after 15-30 mg/kg once-daily dosing, measured 30 minutes post-infusion. Standard once-daily dose is 15–20 mg/kg; peak 20–30 mg/L is the older conventional dosing target.

When is amikacin preferred over gentamicin or tobramycin?

Amikacin is used when isolates are resistant to other aminoglycosides, for multidrug-resistant gram-negative organisms including MDR Pseudomonas and Acinetobacter, and for Mycobacterium infections (including MAC and MTB).

Amikacin Dosing — Peak 20-30 mg/L Target

Calculate amikacin dosing targeting peak 20–30 mg/L (once-daily) or peak 20–30 / trough <5 mg/L (conventional) for serious gram-negative infections, multidrug-resistant organisms, and Mycobacterium infections.

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Amikacin Dosing — Peak 20-30 mg/L Target

Frequently Asked Questions

What amikacin peak target is used for once-daily dosing?

When is amikacin preferred over gentamicin or tobramycin?