Which ANCA pattern is associated with which vasculitis?

cANCA/PR3: predominantly GPA (granulomatosis with polyangiitis, formerly Wegener's). pANCA/MPO: predominantly MPA (microscopic polyangiitis) and EGPA (Churg-Strauss). Both can occur in either disease but have different relapse and outcome profiles.

Does ANCA titer correlate with disease activity?

PR3-ANCA titers often correlate with GPA flares. MPO-ANCA in MPA shows less reliable correlation. ANCA monitoring can guide pre-emptive therapy but should always be interpreted with clinical features.

What is double-positive ANCA significance?

Double positivity (MPO + PR3 ANCA) is rare (<5%) and associated with drug-induced vasculitis (minocycline, hydralazine, PTU) or overlap syndromes. Drug history is critical in double-positive cases.

ANCA MPO/PR3 Pattern Vasculitis Classifier

Interpret ANCA pattern (pANCA/MPO vs cANCA/PR3) to classify ANCA-associated vasculitis: granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), or eosinophilic GPA (EGPA). Guides immunosuppression strategy.

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Frequently Asked Questions

Which ANCA pattern is associated with which vasculitis?

Does ANCA titer correlate with disease activity?

What is double-positive ANCA significance?