What is the linear trapezoidal rule for AUC calculation?

AUC between two time points = (C1 + C2) / 2 × (t2 - t1). Summing all trapezoids gives AUCt; extrapolating from last concentration to infinity: AUC(last to inf) = Clast / λz, where λz is the terminal elimination rate constant.

When is AUC preferred over peak/trough for therapeutic drug monitoring?

AUC-guided monitoring (especially AUC/MIC for vancomycin) better predicts both efficacy and nephrotoxicity than trough-only monitoring, and is now the preferred approach for vancomycin in MRSA infections per 2020 ASHP/IDSA guidelines.

AUC Trapezoidal Rule — Drug Exposure Calculator

Calculate the Area Under the Concentration-Time Curve (AUC) using the linear trapezoidal rule from serial drug concentration measurements to quantify total drug exposure for pharmacokinetic analysis.

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AUC Trapezoidal Rule — Drug Exposure Calculator

Frequently Asked Questions

What is the linear trapezoidal rule for AUC calculation?

When is AUC preferred over peak/trough for therapeutic drug monitoring?