BRCA1/2 Lifetime Breast Cancer Risk (Penetrance)

Estimate lifetime breast and ovarian cancer risk for BRCA1 and BRCA2 pathogenic variant carriers using age-specific penetrance tables from the CIMBA meta-analysis and EMBRACE study data.

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Clinical Guidance

BMI is a screening measure of body size, not a direct measure of body fat. The standard WHO categories are underweight (<18.5), normal (18.5–24.9), overweight (25–29.9), and obese (≥30).

BMI can overestimate body fat in athletes with high muscle mass and underestimate it in older adults with low muscle mass. Interpret it alongside waist circumference and clinical context rather than as a standalone diagnosis.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.
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How It Works

Estimate lifetime breast and ovarian cancer risk for BRCA1 and BRCA2 pathogenic variant carriers using age-specific penetrance tables from the CIMBA meta-analysis and EMBRACE study data

Each component has a specific meaning:

  • Age-specific penetrance tables from the CIMBA meta-analysis — The age-specific penetrance tables from the cimba meta-analysis recorded for the scenario being assessed.
  • EMBRACE study data — The embrace study data recorded for the scenario being assessed.

Note: Interpret the brca penetrance result against the thresholds and context described above.

How to Use

Enter the age-specific penetrance tables from the CIMBA meta-analysis, EMBRACE study data for the scenario you are assessing. Estimate lifetime breast and ovarian cancer risk for BRCA1 and BRCA2 pathogenic variant carriers using age-specific penetrance tables from the CIMBA meta-analysis and EMBRACE study data. Use the brca penetrance result to inform your calculation.

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