What is the lifetime breast cancer risk for BRCA1 carriers?

BRCA1 carriers have approximately 72% (95% CI 65–79%) lifetime risk of breast cancer and 44% (36–53%) lifetime ovarian cancer risk by age 80, based on CIMBA meta-analysis.

How does BRCA2 penetrance differ from BRCA1?

BRCA2 carriers have ~69% lifetime breast cancer risk and ~17% ovarian cancer risk. BRCA2 also confers elevated male breast cancer risk (~7%) and pancreatic cancer risk.

BRCA1/2 Lifetime Breast Cancer Risk (Penetrance)

Estimate lifetime breast and ovarian cancer risk for BRCA1 and BRCA2 pathogenic variant carriers using age-specific penetrance tables from the CIMBA meta-analysis and EMBRACE study data.

Use the full interactive calculator below, or

Related Calculators

BMI Calculator

Medical

BRCA1/2 Lifetime Breast Cancer Risk (Penetrance)

Related Calculators

Frequently Asked Questions

What is the lifetime breast cancer risk for BRCA1 carriers?

How does BRCA2 penetrance differ from BRCA1?