What is the 2021 CKD-EPI race-free formula?

CKD-EPI 2021 (race-free): eGFR = 142 × min(SCr/κ, 1)^α × max(SCr/κ, 1)^-1.200 × 0.9938^age × 1.012 (female); κ = 0.7 female, 0.9 male; α = -0.241 female, -0.302 male; all in mL/min/1.73m².

Why was the race coefficient removed from CKD-EPI 2021?

The Black race coefficient was based on observational differences that may reflect socioeconomic and structural factors rather than biology; removing it reduces systematic bias that historically led to underdiagnosis of CKD in Black patients and reduced access to treatment.

When should cystatin C be added to improve GFR estimation?

CKD-EPI Creatinine-Cystatin C combined equation is most accurate for: confirming CKD diagnosis near decision thresholds (especially 30 and 60 mL/min), patients with abnormal muscle mass, and before major clinical decisions (transplant listing, drug dosing).

What KDIGO criteria define CKD?

CKD = kidney damage or eGFR 3 months; kidney damage markers: albuminuria ACR >30 mg/g, urine sediment abnormalities, imaging abnormalities, electrolyte disorders from tubular disease, or history of kidney transplant.

What is the urgency criterion for nephrology referral in CKD?

KDIGO/NKF recommend referral when: eGFR 5 mL/min/1.73m²/year, ACR ≥300 mg/g (severely increased albuminuria), difficult-to-control hypertension, or unexplained AKI superimposed on CKD.

CKD-EPI 2021 Race-Free eGFR Calculator

Calculates eGFR using the 2021 CKD-EPI Creatinine equation (race-free) and optionally adds cystatin C (CKD-EPI Creatinine-Cystatin) for improved accuracy in edge cases.

Weight

Height

Clinical Guidance

BMI is a screening measure of body size, not a direct measure of body fat. The standard WHO categories are underweight (<18.5), normal (18.5–24.9), overweight (25–29.9), and obese (≥30).

BMI can overestimate body fat in athletes with high muscle mass and underestimate it in older adults with low muscle mass. Interpret it alongside waist circumference and clinical context rather than as a standalone diagnosis.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.

How It Works

Calculates eGFR using the 2021 CKD-EPI Creatinine equation (race-free) and optionally adds cystatin C (CKD-EPI Creatinine-Cystatin) for improved accuracy in edge cases

Each component has a specific meaning:

2021 CKD-EPI Creatinine equation — The 2021 ckd-epi creatinine equation recorded for the patient or scenario being assessed.
Optionally adds cystatin C — The optionally adds cystatin c recorded for the patient or scenario being assessed.

Note: Interpret the ckd-epi 2021 egfr result against the clinical thresholds and context described above.

How to Use

Enter the 2021 CKD-EPI Creatinine equation, optionally adds cystatin C for the patient or scenario you are assessing. Calculates eGFR using the 2021 CKD-EPI Creatinine equation (race-free) and optionally adds cystatin C (CKD-EPI Creatinine-Cystatin) for improved accuracy in edge cases. Use the ckd-epi 2021 egfr result to inform your clinical assessment.

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CKD-EPI 2021 Race-Free eGFR Calculator

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How to Use

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Frequently Asked Questions

What is the 2021 CKD-EPI race-free formula?

Why was the race coefficient removed from CKD-EPI 2021?

When should cystatin C be added to improve GFR estimation?

What KDIGO criteria define CKD?

What is the urgency criterion for nephrology referral in CKD?