What does the CMTNS-v2 assess?

CMTNS-v2 scores 9 items: upper limb symptoms (0–4), pin sensibility (0–4), vibration (0–4), strength (arm and leg each 0–4), and nerve conduction (SNAP and CMAP amplitudes, each 0–4). Total 0–36.

What is the MCID for CMTNS-v2?

A change of ≥2 points in CMTNS-v2 is considered clinically meaningful, corresponding to a 0.5-point change on the CGI-C scale in CMT natural history studies.

CMTNS — Charcot-Marie-Tooth Neuropathy Score

Score Charcot-Marie-Tooth disease severity using the CMT Neuropathy Score (CMTNS-v2) covering symptoms, signs, and nerve conduction studies across upper and lower extremity domains.

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CMTNS — Charcot-Marie-Tooth Neuropathy Score

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Frequently Asked Questions

What does the CMTNS-v2 assess?

What is the MCID for CMTNS-v2?