What are DAS28-CRP disease activity thresholds?

DAS28-CRP remission 4.1; biologic/targeted synthetic DMARD initiation typically triggered at sustained DAS28 >3.2 despite conventional DMARD therapy.

How many joints are assessed in DAS28?

28 joints assessed: bilateral proximal interphalangeal (10), metacarpophalangeal (10), wrists (2), elbows (2), shoulders (2), and knees (2); each scored for tenderness and swelling separately.

Is DAS28-CRP interchangeable with DAS28-ESR?

DAS28-CRP and DAS28-ESR are not directly interchangeable; DAS28-CRP is slightly lower for the same clinical state; different cut-points are required; CRP-based may be more sensitive to acute changes.

What is treat-to-target in rheumatoid arthritis?

Treat-to-target (T2T) means aiming for DAS28 remission (<2.6) or low disease activity (<3.2) by adjusting therapy at each visit until target achieved; monthly adjustment until target, then 3-6 monthly once stable.

What DMARDs are first-line for rheumatoid arthritis?

Methotrexate 7.5-25 mg/week (with folate) is anchor drug; hydroxychloroquine, sulfasalazine, leflunomide as alternatives or combination; biologics (TNFi, IL-6i, JAKi, abatacept) for inadequate responders.

DAS28-CRP Disease Activity Score for Rheumatoid Arthritis

Calculates the 28-joint Disease Activity Score using CRP (DAS28-CRP) for rheumatoid arthritis to determine disease activity state (remission/low/moderate/high) and guide biologic therapy initiation.

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