What weight is used for aminoglycoside dosing in obesity?

Adjusted Body Weight (AdjBW = IBW + 0.4 × (TBW - IBW)) is used for aminoglycoside dosing in obesity, as adipose tissue has limited aminoglycoside distribution. IBW dramatically underdoses; TBW dramatically overdoses.

What weight is used for vancomycin dosing in obesity?

Total Body Weight (TBW) is used for vancomycin loading dose and AUC-guided dosing in obesity, as vancomycin Vd scales with TBW in obese patients. Starting doses of 25-30 mg/kg TBW are commonly used for severe infections.

Drug Dose Adjustment for Obesity — TBW vs IBW vs AdjBW

Determine whether to use Total Body Weight (TBW), Ideal Body Weight (IBW), or Adjusted Body Weight (AdjBW = IBW + 0.4(TBW-IBW)) for drug dose calculations in obese patients to optimize efficacy and minimize toxicity.

Use the full interactive calculator below, or

Drug Dose Adjustment for Obesity — TBW vs IBW vs AdjBW

Frequently Asked Questions

What weight is used for aminoglycoside dosing in obesity?

What weight is used for vancomycin dosing in obesity?