GBA-Parkinson Disease Risk and Progression Calculator

Estimate Parkinson disease risk and progression rate for GBA pathogenic variant carriers, distinguishing mild (N370S, L444P) from severe (biallelic) mutations and their impact on cognitive decline and motor progression.

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Height
Clinical Guidance

BMI is a screening measure of body size, not a direct measure of body fat. The standard WHO categories are underweight (<18.5), normal (18.5–24.9), overweight (25–29.9), and obese (≥30).

BMI can overestimate body fat in athletes with high muscle mass and underestimate it in older adults with low muscle mass. Interpret it alongside waist circumference and clinical context rather than as a standalone diagnosis.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.
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How It Works

Estimate Parkinson disease risk and progression rate for GBA pathogenic variant carriers, distinguishing mild (N370S, L444P) from severe (biallelic) mutations and their impact on cognitive decline and motor progression

Each component has a specific meaning:

  • Severe mutations — The severe mutations recorded for the scenario being assessed.
  • Impact on cognitive decline — The impact on cognitive decline recorded for the scenario being assessed.
  • Motor progression — The motor progression recorded for the scenario being assessed.

Note: Interpret the gba-pd risk result against the thresholds and context described above.

How to Use

Enter the severe mutations, impact on cognitive decline, motor progression for the scenario you are assessing. Estimate Parkinson disease risk and progression rate for GBA pathogenic variant carriers, distinguishing mild (N370S, L444P) from severe (biallelic) mutations and their impact on cognitive decline and motor progression. Use the gba-pd risk result to inform your calculation.

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