How does the Hartford Nomogram determine gentamicin dosing interval?

Give 7 mg/kg IV, then measure a random level at 6-14 hours post-dose. Plot on the Hartford Nomogram: if the level falls in the q24h zone, give q24h; q36h zone = every 36 hours; q48h zone = every 48 hours.

What are the advantages of once-daily aminoglycoside dosing?

Once-daily dosing maximizes the Cmax/MIC ratio (concentration-dependent killing), enhances post-antibiotic effect, reduces adaptive resistance, and has similar or lower nephrotoxicity and ototoxicity versus traditional multiple-daily dosing.

Gentamicin Hartford Nomogram — Once-Daily Dosing

Apply the Hartford Nomogram for once-daily gentamicin dosing (7 mg/kg) with 6-14 hour post-dose level monitoring to guide dose interval selection (q24h, q36h, or q48h) based on renal function.

Use the full interactive calculator below, or

Gentamicin Hartford Nomogram — Once-Daily Dosing

Frequently Asked Questions

How does the Hartford Nomogram determine gentamicin dosing interval?

What are the advantages of once-daily aminoglycoside dosing?