HFE Haemochromatosis C282Y Penetrance and Iron Loading

Calculate iron overload risk, clinical penetrance, and phlebotomy requirement estimates for HFE haemochromatosis genotypes (C282Y/C282Y, C282Y/H63D, H63D/H63D) based on sex, transferrin saturation, and ferritin level.

Weight
Height
Clinical Guidance

BMI is a screening measure of body size, not a direct measure of body fat. The standard WHO categories are underweight (<18.5), normal (18.5–24.9), overweight (25–29.9), and obese (≥30).

BMI can overestimate body fat in athletes with high muscle mass and underestimate it in older adults with low muscle mass. Interpret it alongside waist circumference and clinical context rather than as a standalone diagnosis.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.
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How It Works

Calculate iron overload risk, clinical penetrance, and phlebotomy requirement estimates for HFE haemochromatosis genotypes (C282Y/C282Y, C282Y/H63D, H63D/H63D) based on sex, transferrin saturation, and ferritin level

Each component has a specific meaning:

  • Sex — The sex recorded for the scenario being assessed.
  • Transferrin saturation — The transferrin saturation recorded for the scenario being assessed.
  • Ferritin level — The ferritin level recorded for the scenario being assessed.

Note: Interpret the hfe haemochromatosis risk result against the thresholds and context described above.

How to Use

Enter the sex, transferrin saturation, ferritin level for the scenario you are assessing. Calculate iron overload risk, clinical penetrance, and phlebotomy requirement estimates for HFE haemochromatosis genotypes (C282Y/C282Y, C282Y/H63D, H63D/H63D) based on sex, transferrin saturation, and ferritin level. Use the hfe haemochromatosis risk result to inform your calculation.

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