Hypophosphatasia (HPP) Severity Classification and Asfotase Alfa Dosing

Classifies hypophosphatasia severity (perinatal/infantile/childhood/adult/odontohypophosphatasia) using ALP levels, phosphoethanolamine, PPi, TNSALP gene mutations, and asfotase alfa dosing by weight and phenotype.

Weight
Height
Clinical Guidance

BMI is a screening measure of body size, not a direct measure of body fat. The standard WHO categories are underweight (<18.5), normal (18.5–24.9), overweight (25–29.9), and obese (≥30).

BMI can overestimate body fat in athletes with high muscle mass and underestimate it in older adults with low muscle mass. Interpret it alongside waist circumference and clinical context rather than as a standalone diagnosis.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.
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How It Works

Classifies hypophosphatasia severity (perinatal/infantile/childhood/adult/odontohypophosphatasia) using ALP levels, phosphoethanolamine, PPi, TNSALP gene mutations, and asfotase alfa dosing by weight and phenotype

Each component has a specific meaning:

  • ALP levels — The alp levels recorded for the scenario being assessed.
  • Phosphoethanolamine — The phosphoethanolamine recorded for the scenario being assessed.
  • PPi — The ppi recorded for the scenario being assessed.
  • TNSALP gene mutations — The tnsalp gene mutations recorded for the scenario being assessed.
  • Asfotase alfa dosing by weight — The asfotase alfa dosing by weight recorded for the scenario being assessed.
  • Phenotype — The phenotype recorded for the scenario being assessed.

Note: Interpret the hpp severity result against the thresholds and context described above.

How to Use

Enter the ALP levels, phosphoethanolamine, PPi, TNSALP gene mutations, asfotase alfa dosing by weight, phenotype for the scenario you are assessing. Classifies hypophosphatasia severity (perinatal/infantile/childhood/adult/odontohypophosphatasia) using ALP levels, phosphoethanolamine, PPi, TNSALP gene mutations, and asfotase alfa dosing by weight and phenotype. Use the hpp severity result to inform your calculation.

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Frequently Asked Questions