Lynch Syndrome MLH1 Mutation Probability Calculator

Estimate Lynch syndrome probability using MMR immunohistochemistry, MSI status, MLH1 promoter methylation, BRAF V600E, and family history. Positive MLH1 IHC loss without methylation = ~40% Lynch syndrome probability.

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Clinical Guidance

BMI is a screening measure of body size, not a direct measure of body fat. The standard WHO categories are underweight (<18.5), normal (18.5–24.9), overweight (25–29.9), and obese (≥30).

BMI can overestimate body fat in athletes with high muscle mass and underestimate it in older adults with low muscle mass. Interpret it alongside waist circumference and clinical context rather than as a standalone diagnosis.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.
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How It Works

Estimate Lynch syndrome probability using MMR immunohistochemistry, MSI status, MLH1 promoter methylation, BRAF V600E, and family history. Positive MLH1 IHC loss without methylation = ~40% Lynch syndrome probability

Each component has a specific meaning:

  • MMR immunohistochemistry — The mmr immunohistochemistry recorded for the scenario being assessed.
  • MSI status — The msi status recorded for the scenario being assessed.
  • MLH1 promoter methylation — The mlh1 promoter methylation recorded for the scenario being assessed.
  • BRAF V600E — The braf v600e recorded for the scenario being assessed.
  • Family history — The family history recorded for the scenario being assessed.

Note: Interpret the lynch syndrome risk result against the thresholds and context described above.

How to Use

Enter the MMR immunohistochemistry, MSI status, MLH1 promoter methylation, BRAF V600E, family history for the scenario you are assessing. Estimate Lynch syndrome probability using MMR immunohistochemistry, MSI status, MLH1 promoter methylation, BRAF V600E, and family history. Positive MLH1 IHC loss without methylation = ~40% Lynch syndrome probability. Use the lynch syndrome risk result to inform your calculation.

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Frequently Asked Questions