Lynch Syndrome Cumulative Cancer Risk Calculator

Calculate cumulative lifetime cancer risks for Lynch syndrome (HNPCC) based on pathogenic variant in MLH1, MSH2, MSH6, or PMS2, incorporating sex and age-specific penetrance data from prospective studies.

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Clinical Guidance

BMI is a screening measure of body size, not a direct measure of body fat. The standard WHO categories are underweight (<18.5), normal (18.5–24.9), overweight (25–29.9), and obese (≥30).

BMI can overestimate body fat in athletes with high muscle mass and underestimate it in older adults with low muscle mass. Interpret it alongside waist circumference and clinical context rather than as a standalone diagnosis.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.
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How It Works

Calculate cumulative lifetime cancer risks for Lynch syndrome (HNPCC) based on pathogenic variant in MLH1, MSH2, MSH6, or PMS2, incorporating sex and age-specific penetrance data from prospective studies

Each component has a specific meaning:

  • Pathogenic variant in MLH1 — The pathogenic variant in mlh1 recorded for the scenario being assessed.
  • MSH2 — The msh2 recorded for the scenario being assessed.
  • MSH6 — The msh6 recorded for the scenario being assessed.
  • Or PMS2 — The or pms2 recorded for the scenario being assessed.
  • Incorporating sex — The incorporating sex recorded for the scenario being assessed.
  • Age-specific penetrance data from prospective studies — The age-specific penetrance data from prospective studies recorded for the scenario being assessed.

Note: Interpret the lynch syndrome risk result against the thresholds and context described above.

How to Use

Enter the pathogenic variant in MLH1, MSH2, MSH6, or PMS2, incorporating sex, age-specific penetrance data from prospective studies for the scenario you are assessing. Calculate cumulative lifetime cancer risks for Lynch syndrome (HNPCC) based on pathogenic variant in MLH1, MSH2, MSH6, or PMS2, incorporating sex and age-specific penetrance data from prospective studies. Use the lynch syndrome risk result to inform your calculation.

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