Lysosomal Acid Lipase Deficiency Assessment (Wolman/CESD)

Assesses lysosomal acid lipase deficiency severity (Wolman disease in infants; CESD in older patients) using liver function tests, lipid profile, liver ultrasound/biopsy findings, and sebilapase alfa dosing.

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Clinical Guidance

BMI is a screening measure of body size, not a direct measure of body fat. The standard WHO categories are underweight (<18.5), normal (18.5–24.9), overweight (25–29.9), and obese (≥30).

BMI can overestimate body fat in athletes with high muscle mass and underestimate it in older adults with low muscle mass. Interpret it alongside waist circumference and clinical context rather than as a standalone diagnosis.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.
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How It Works

Assesses lysosomal acid lipase deficiency severity (Wolman disease in infants; CESD in older patients) using liver function tests, lipid profile, liver ultrasound/biopsy findings, and sebilapase alfa dosing

Each component has a specific meaning:

  • Liver function tests — The liver function tests recorded for the scenario being assessed.
  • Lipid profile — The lipid profile recorded for the scenario being assessed.
  • Liver ultrasound/biopsy findings — The liver ultrasound/biopsy findings recorded for the scenario being assessed.
  • Sebilapase alfa dosing — The sebilapase alfa dosing recorded for the scenario being assessed.

Note: Interpret the lal deficiency result against the thresholds and context described above.

How to Use

Enter the liver function tests, lipid profile, liver ultrasound/biopsy findings, sebilapase alfa dosing for the scenario you are assessing. Assesses lysosomal acid lipase deficiency severity (Wolman disease in infants; CESD in older patients) using liver function tests, lipid profile, liver ultrasound/biopsy findings, and sebilapase alfa dosing. Use the lal deficiency result to inform your calculation.

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Frequently Asked Questions