How does M2-PK compare to FIT for CRC screening?

M2-PK sensitivity for CRC: 85% vs FIT 79%. For advanced adenoma: M2-PK 57% vs FIT 27%. Combined M2-PK + FIT achieves 90%+ sensitivity for CRC with acceptable specificity.

Is M2-PK affected by hemoglobin degradation?

No — M2-PK is heat-stable and not affected by storage conditions or hemoglobin degradation that affects FIT accuracy. Suitable for hot climates where FIT sample stability is a concern.

Is M2-PK approved for CRC screening?

CE marked in Europe. Not FDA-cleared for standalone CRC screening in the US. Used in European multi-marker screening programs and research protocols.

M2-PK Tumor Marker CRC Screening Calculator

Interpret fecal tumor M2-pyruvate kinase (M2-PK) for colorectal cancer screening. Cut-off 4 U/mL: sensitivity 85% for CRC, 57% for advanced adenoma. Used alongside FIT in multi-marker protocols.

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Frequently Asked Questions

How does M2-PK compare to FIT for CRC screening?

Is M2-PK affected by hemoglobin degradation?

Is M2-PK approved for CRC screening?