What Maddrey's DF score indicates corticosteroid benefit?

DF ≥32 indicates severe alcoholic hepatitis with 30-day mortality of 30–50% without treatment. Prednisolone 40 mg/day for 28 days is recommended if no contraindications, with Lille model reassessment at day 7.

What contraindications prevent corticosteroid use in alcoholic hepatitis?

Active infection (especially GI bleeding, spontaneous bacterial peritonitis, severe sepsis), renal failure, GI hemorrhage, HBV reactivation risk, and uncontrolled diabetes are relative or absolute contraindications.

Maddrey's Discriminant Function — Alcoholic Hepatitis

Calculate Maddrey's Discriminant Function (4.6 × (PT − control PT) + bilirubin mg/dL) to identify severe alcoholic hepatitis (DF ≥32) where corticosteroid therapy may improve 30-day survival.

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Maddrey's Discriminant Function — Alcoholic Hepatitis

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Frequently Asked Questions

What Maddrey's DF score indicates corticosteroid benefit?

What contraindications prevent corticosteroid use in alcoholic hepatitis?