RASopathy (Noonan/LEOPARD/CFC Syndrome) Risk Assessment

Assess pre-test probability of RASopathy (Noonan syndrome, LEOPARD syndrome, Costello syndrome, cardiofaciocutaneous syndrome) based on phenotypic features and guide targeted gene panel selection.

Weight
Height
Clinical Guidance

BMI is a screening measure of body size, not a direct measure of body fat. The standard WHO categories are underweight (<18.5), normal (18.5–24.9), overweight (25–29.9), and obese (≥30).

BMI can overestimate body fat in athletes with high muscle mass and underestimate it in older adults with low muscle mass. Interpret it alongside waist circumference and clinical context rather than as a standalone diagnosis.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.
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How It Works

Assess pre-test probability of RASopathy (Noonan syndrome, LEOPARD syndrome, Costello syndrome, cardiofaciocutaneous syndrome) based on phenotypic features and guide targeted gene panel selection

Each component has a specific meaning:

  • Phenotypic features — The phenotypic features recorded for the scenario being assessed.
  • Guide targeted gene panel selection — The guide targeted gene panel selection recorded for the scenario being assessed.

Note: Interpret the rasopathy risk result against the thresholds and context described above.

How to Use

Enter the phenotypic features, guide targeted gene panel selection for the scenario you are assessing. Assess pre-test probability of RASopathy (Noonan syndrome, LEOPARD syndrome, Costello syndrome, cardiofaciocutaneous syndrome) based on phenotypic features and guide targeted gene panel selection. Use the rasopathy risk result to inform your calculation.

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