What triggers activation of a massive transfusion protocol?

MTP is typically activated for actual or predicted transfusion of ≥10 units of RBC in 24 hours, transfusion of ≥4 units in 1 hour with continued bleeding, or by validated scoring systems such as the ABC score ≥2.

What is the evidence behind the 1:1:1 ratio in MTP?

The PROPPR trial demonstrated that 1:1:1 RBC:FFP:Platelets reduced 24-hour mortality compared to 1:1:2, primarily by achieving earlier hemostasis, and is now the standard ratio in most trauma MTP protocols.

Massive Transfusion Protocol — Blood Product Ratio Calculator

Calculate blood product requirements for massive transfusion protocols (MTP) using 1:1:1 ratio (RBC:FFP:Platelets) targeting damage control resuscitation in hemorrhagic shock and trauma.

Use the full interactive calculator below, or

Massive Transfusion Protocol — Blood Product Ratio Calculator

Frequently Asked Questions

What triggers activation of a massive transfusion protocol?

What is the evidence behind the 1:1:1 ratio in MTP?