What does AMH reflect physiologically?

AMH is secreted by granulosa cells of small antral and pre-antral follicles, making it a direct measure of the remaining primordial follicle pool (ovarian reserve). Unlike FSH and estradiol, AMH does not vary significantly across the menstrual cycle.

What AMH level predicts poor IVF response?

AMH below 0.5-1.0 ng/mL is associated with poor ovarian response to stimulation (typically 3-4 oocytes retrieved or fewer). AMH above 3.5-4.0 ng/mL suggests high response and elevated risk of ovarian hyperstimulation syndrome (OHSS).

What factors affect AMH levels?

AMH is reduced by: advanced age (natural decline), smoking, chemotherapy, ovarian surgery, endometriosis, and some oral contraceptives. AMH is elevated in PCOS. AMH levels decline with age from puberty peak at approximately 25 years.

AMH Interpretation for Ovarian Reserve

Interpret anti-Mullerian hormone for ovarian reserve: low below 1.0 ng/mL (poor reserve, low IVF response), optimal 1.0-3.5 ng/mL, high above 3.5 ng/mL (PCOS risk, hyperstimulation).

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Frequently Asked Questions

What does AMH reflect physiologically?

What AMH level predicts poor IVF response?

What factors affect AMH levels?