What is the normal anion gap?

Normal AG is 8-12 mEq/L without albumin correction. Correct for hypoalbuminemia: add 2.5 mEq/L per 1 g/dL decrease in albumin below 4.

What causes elevated anion gap acidosis?

MUDPILES: Methanol, Uremia, DKA, Propylene glycol, Isoniazid/Infection, Lactic acidosis, Ethylene glycol, Salicylates.

Delta-delta = (AG - 12) / (24 - HCO3). If 2: AG acidosis + metabolic alkalosis.

Calculate anion gap (AG = Na - Cl - HCO3) with albumin correction — essential for metabolic acidosis differential.

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