Argatroban Dosing for HIT (Heparin-Induced Thrombocytopenia)

Calculates argatroban dosing for heparin-induced thrombocytopenia (HIT). Standard initial dose: 2 mcg/kg/min IV infusion. Reduce to 0.5 mcg/kg/min with hepatic impairment (elevated bilirubin or liver failure). Target aPTT 1.5–3× baseline (typically 45–90 seconds). Check aPTT 2 hours after initiation and each dose adjustment.