Argatroban Dosing for HIT (Heparin-Induced Thrombocytopenia)

Calculates argatroban dosing for heparin-induced thrombocytopenia (HIT). Standard initial dose: 2 mcg/kg/min IV infusion. Reduce to 0.5 mcg/kg/min with hepatic impairment (elevated bilirubin or liver failure). Target aPTT 1.5–3× baseline (typically 45–90 seconds). Check aPTT 2 hours after initiation and each dose adjustment.

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Clinical Guidance

BMI is a screening measure of body size, not a direct measure of body fat. The standard WHO categories are underweight (<18.5), normal (18.5–24.9), overweight (25–29.9), and obese (≥30).

BMI can overestimate body fat in athletes with high muscle mass and underestimate it in older adults with low muscle mass. Interpret it alongside waist circumference and clinical context rather than as a standalone diagnosis.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.
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How to Use

Enter the values for the scenario you are assessing. Calculates argatroban dosing for heparin-induced thrombocytopenia (HIT). Standard initial dose: 2 mcg/kg/min IV infusion. Reduce to 0.5 mcg/kg/min with hepatic impairment (elevated bilirubin or liver failure). Target aPTT 1.5–3× baseline (typically 45–90 seconds). Check aPTT 2 hours after initiation and each dose adjustment. Use the argatroban hit result to inform your calculation.

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