What is the standard argatroban dosing for HIT?

Standard: 2 mcg/kg/min continuous infusion. Hepatic impairment (total bilirubin >1.5 mg/dL): 0.5 mcg/kg/min. Critical illness/post-cardiac surgery: start 0.5–1.0 mcg/kg/min. Target aPTT 1.5–3.0× baseline (45–100 seconds). Check aPTT 2 hours after initiation and after any dose change.

How does argatroban affect the INR during warfarin transition?

Argatroban falsely elevates INR (typically 1.5–2.0× above warfarin effect alone). For transition: when argatroban infusion rate is ≤2 mcg/kg/min, stop infusion and measure INR 4–6 hours later. If INR >4 on warfarin alone, argatroban can be stopped. Therapeutic INR target is ≥4 while on argatroban + warfarin.

Argatroban Dose in Heparin-Induced Thrombocytopenia

Calculate argatroban infusion rate for HIT treatment based on patient weight, hepatic function, and target aPTT (1.5–3.0× baseline). Reduce dose 75% in hepatic impairment.

Use the full interactive calculator below, or

Argatroban Dose in Heparin-Induced Thrombocytopenia

Frequently Asked Questions

What is the standard argatroban dosing for HIT?

How does argatroban affect the INR during warfarin transition?