Capecitabine DPYD Deficiency Fatal Risk Calculator

Assess life-threatening fluoropyrimidine toxicity risk from DPYD variants. Complete deficiency (*2A/*2A) is a contraindication to capecitabine.

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Clinical Guidance

BMI is a screening measure of body size, not a direct measure of body fat. The standard WHO categories are underweight (<18.5), normal (18.5–24.9), overweight (25–29.9), and obese (≥30).

BMI can overestimate body fat in athletes with high muscle mass and underestimate it in older adults with low muscle mass. Interpret it alongside waist circumference and clinical context rather than as a standalone diagnosis.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.
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How It Works

Assess life-threatening fluoropyrimidine toxicity risk from DPYD variants. Complete deficiency (*2A/*2A) is a contraindication to capecitabine

Each component has a specific meaning:

  • DPYD variants — The dpyd variants recorded for the scenario being assessed.

Note: Interpret the capecitabine dpyd result against the thresholds and context described above.

How to Use

Enter the DPYD variants for the scenario you are assessing. Assess life-threatening fluoropyrimidine toxicity risk from DPYD variants. Complete deficiency (*2A/*2A) is a contraindication to capecitabine. Use the capecitabine dpyd result to inform your calculation.

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