Capecitabine Hand-Foot Syndrome Threshold

Determine capecitabine dose modification based on hand-foot syndrome (palmar-plantar erythrodysesthesia) grade: grade 1 maintain dose, grade 2 interrupt, grade 3 interrupt and reduce by 25%.

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Clinical Guidance

BMI is a screening measure of body size, not a direct measure of body fat. The standard WHO categories are underweight (<18.5), normal (18.5–24.9), overweight (25–29.9), and obese (≥30).

BMI can overestimate body fat in athletes with high muscle mass and underestimate it in older adults with low muscle mass. Interpret it alongside waist circumference and clinical context rather than as a standalone diagnosis.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.
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How It Works

Determine capecitabine dose modification based on hand-foot syndrome (palmar-plantar erythrodysesthesia) grade: grade 1 maintain dose, grade 2 interrupt, grade 3 interrupt and reduce by 25%

Each component has a specific meaning:

  • Hand-foot syndrome grade: grade 1 maintain dose — The hand-foot syndrome grade: grade 1 maintain dose recorded for the scenario being assessed.
  • Grade 2 interrupt — The grade 2 interrupt recorded for the scenario being assessed.
  • Grade 3 interrupt — The grade 3 interrupt recorded for the scenario being assessed.
  • Reduce by 25% — The reduce by 25% recorded for the scenario being assessed.

Note: Interpret the capecitabine hfs result against the thresholds and context described above.

How to Use

Enter the hand-foot syndrome grade: grade 1 maintain dose, grade 2 interrupt, grade 3 interrupt, reduce by 25% for the scenario you are assessing. Determine capecitabine dose modification based on hand-foot syndrome (palmar-plantar erythrodysesthesia) grade: grade 1 maintain dose, grade 2 interrupt, grade 3 interrupt and reduce by 25%. Use the capecitabine hfs result to inform your calculation.

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