What AUC target is used for carboplatin?

AUC 5-6 mg.min/mL is standard for most regimens (e.g., carboplatin + paclitaxel). AUC 7 is sometimes used for single-agent carboplatin when marrow reserve is adequate.

Why is eGFR used in the Calvert formula?

Carboplatin is renally cleared; higher GFR means faster drug elimination and thus higher dose needed to achieve the target AUC exposure.

Should I use CrCl or eGFR in Calvert?

The FDA recommends using the Cockcroft-Gault CrCl (capped at 125 mL/min in some guidelines) to avoid overdosing from overestimated GFR.

Carboplatin Dose - Calvert Formula

Calculate carboplatin dose using the Calvert formula: Dose (mg) = AUC x (eGFR + 25). AUC target 5-7 for combination, 5-6 for relapsed. Uses Cockcroft-Gault or CKD-EPI eGFR in mL/min.

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Frequently Asked Questions

What AUC target is used for carboplatin?

Why is eGFR used in the Calvert formula?

Should I use CrCl or eGFR in Calvert?