Apply high-sensitivity troponin (hs-cTn) kinetics to diagnose acute MI using 0/1-hour or 0/2-hour algorithms. Rise of 20% or more absolute change over 1-3 hours from a detectable baseline = acute MI pattern. ESC 0h/1h algorithm: Rule-in at 0h if hs-cTnT is 52 ng/L or higher or rise of 5 ng/L or more at 1h; Rule-out if 0h is below 5 ng/L and rise is below 2 ng/L.
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