What is net reclassification improvement?

NRI measures how much a new biomarker or test improves risk classification by correctly moving patients to higher or lower risk categories compared to the baseline model.

What NRI did calcium score achieve in MESA?

In MESA, adding CAC to the Framingham Risk Score improved NRI by approximately 0.25-0.30 in intermediate-risk populations, representing a clinically meaningful gain.

How is reclassification used clinically?

Reclassification helps decide whether to initiate statin therapy. A CAC score reclassifying a patient to high risk supports therapy initiation; reclassifying to low risk supports deferral.

Coronary Artery Calcium RECLASSIFY NRI

Estimate net reclassification improvement (NRI) from adding coronary artery calcium score to traditional risk models for cardiovascular risk stratification.

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