Why use cystatin C instead of creatinine for GFR?

Cystatin C is produced at a constant rate by all nucleated cells and freely filtered, making it less dependent on muscle mass, diet, and race than creatinine. It is more accurate in extremes of muscle mass.

What is the CKD-EPI cystatin C equation?

CKD-EPI 2012: eGFR = 133 x min(CysC/0.8, 1)^-0.499 x max(CysC/0.8, 1)^-1.328 x 0.996^Age x 0.932 (if female). Reported in mL/min/1.73 m2.

When is combined creatinine-cystatin C preferred?

The CKD-EPI creatinine-cystatin C combined equation has the lowest bias and highest precision, recommended when GFR estimation is critical (e.g., living kidney donation evaluation).

Cystatin C GFR Estimator (CKD-EPI Cys)

Estimate GFR using serum cystatin C with the CKD-EPI cystatin C equation. Less affected by muscle mass than creatinine-based equations.

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Cystatin C GFR Estimator (CKD-EPI Cys)

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Frequently Asked Questions

Why use cystatin C instead of creatinine for GFR?

What is the CKD-EPI cystatin C equation?

When is combined creatinine-cystatin C preferred?