What CK levels are seen in dermatomyositis?

CK is elevated in 70–90% of DM/PM patients. Mild elevation (2–5× ULN): minimal myositis or skin-predominant disease. Moderate (5–50× ULN): active myositis. Severe (>50× ULN): severe myositis or necrotizing autoimmune myopathy (IMNM). CK may be normal in amyopathic DM.

Does CK normalization indicate remission in DM?

CK normalization is a useful but imperfect marker. MRI and functional testing are more sensitive for residual inflammation. Some patients with clinically active myositis have normal CK, particularly those with anti-Jo-1 or anti-MDA5 antibodies.

Dermatomyositis CK Level Severity Assessment

Interpret CK elevation in dermatomyositis and polymyositis to assess muscle inflammation severity and guide immunosuppressive therapy intensity.

Use the full interactive calculator below, or

Dermatomyositis CK Level Severity Assessment

Frequently Asked Questions

What CK levels are seen in dermatomyositis?

Does CK normalization indicate remission in DM?