Intrapartum GBS prophylaxis is indicated for: positive rectovaginal GBS culture at 35–37 weeks; GBS bacteriuria this pregnancy; prior infant with GBS disease; unknown GBS status with risk factors (delivery <37 weeks, ROM ≥18 hours, intrapartum fever ≥38°C, intrapartum NAAT positive). Penicillin G 5 million units IV then 2.5–3 million units q4h until delivery.
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