What HBV DNA level requires treatment?

HBeAg-positive: >20,000 IU/mL with elevated ALT. HBeAg-negative: >2,000 IU/mL with elevated ALT or significant liver disease. Cirrhotic patients may be treated at lower viral loads.

What is the goal of HBV antiviral therapy?

The goal is sustained HBV DNA suppression to undetectable levels, normalization of ALT, prevention of cirrhosis and hepatocellular carcinoma, and ideally HBsAg loss (functional cure), though this is achieved in <10% of patients on current therapies.

Hepatitis B Viral Load Treatment Threshold

Determines antiviral therapy for chronic HBV: HBeAg-positive with HBV DNA >20,000 IU/mL and elevated ALT; HBeAg-negative with HBV DNA >2,000 IU/mL and elevated ALT or significant fibrosis on biopsy.

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Hepatitis B Viral Load Treatment Threshold

Frequently Asked Questions

What HBV DNA level requires treatment?

What is the goal of HBV antiviral therapy?