Determines HCV treatment regimen and duration by genotype: Genotype 1a/1b — sofosbuvir/ledipasvir 8–12 weeks (treatment-naive, no cirrhosis) or 12–24 weeks (cirrhosis). Genotype 2 — sofosbuvir/velpatasvir 12 weeks. Genotype 3 — 12–24 weeks depending on cirrhosis.
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