How are HAE attacks classified by severity?

HAE attacks are classified: mild (peripheral, minimal daily impact), moderate (abdominal or multifocal peripheral with significant pain), severe (laryngeal edema requiring emergency treatment, or disabling abdominal attacks). All laryngeal attacks are potentially life-threatening.

What determines on-demand therapy for HAE?

All HAE attacks affecting the larynx require immediate treatment with C1-INH concentrate, icatibant, or ecallantide. Abdominal attacks may be treated or observed depending on severity. Mild peripheral attacks may resolve without treatment. Prodromes (erythema marginatum) can predict attack onset.

Hereditary Angioedema Attack Severity Score

Score hereditary angioedema attack severity by location (laryngeal, abdominal, peripheral), duration, pain intensity, and impact on daily activities to guide on-demand therapy selection.

Use the full interactive calculator below, or

Hereditary Angioedema Attack Severity Score

Frequently Asked Questions

How are HAE attacks classified by severity?

What determines on-demand therapy for HAE?