Hydroxyurea Starting Dose Calculator for Sickle Cell Disease

Calculates hydroxyurea starting dose for sickle cell disease: 15–20 mg/kg/day orally (round to nearest 500 mg capsule). Escalate by 5 mg/kg/day every 8–12 weeks to maximum tolerated dose (MTD), targeting HbF ≥20% and MCV increase while monitoring CBC for myelosuppression.

Weight
Height
Clinical Guidance

BMI is a screening measure of body size, not a direct measure of body fat. The standard WHO categories are underweight (<18.5), normal (18.5–24.9), overweight (25–29.9), and obese (≥30).

BMI can overestimate body fat in athletes with high muscle mass and underestimate it in older adults with low muscle mass. Interpret it alongside waist circumference and clinical context rather than as a standalone diagnosis.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.
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How to Use

Enter the values for the scenario you are assessing. Calculates hydroxyurea starting dose for sickle cell disease: 15–20 mg/kg/day orally (round to nearest 500 mg capsule). Escalate by 5 mg/kg/day every 8–12 weeks to maximum tolerated dose (MTD), targeting HbF ≥20% and MCV increase while monitoring CBC for myelosuppression. Use the hydroxyurea dose scd result to inform your calculation.

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