Read an IgA nephropathy biopsy through the Oxford MEST-C criteria: mesangial hypercellularity, endocapillary hypercellularity, segmental sclerosis, tubular atrophy or interstitial fibrosis, and crescents. The T lesion drives most of the prognostic weight.
The Oxford classification scores five biopsy features in IgA nephropathy. M1, S1, T1/T2, and C1/C2 are each independently associated with a worse renal outcome, with T (tubular atrophy and interstitial fibrosis) the most consistently predictive. E1 reflects active endocapillary inflammation and is associated with a better response to immunosuppression rather than with progression. Scoring requires an adequate biopsy (a minimum of 8 glomeruli is recommended).
Source: Working Group of the International IgA Nephropathy Network and the Renal Pathology Society, Kidney Int 2009; updated 2016 to include crescents (C) — Trimarchi et al., Kidney Int 2017. The MEST-C score supplements, but does not replace, clinical risk assessment.
Enter the values for the scenario you are assessing. Read an IgA nephropathy biopsy through the Oxford MEST-C criteria: mesangial hypercellularity, endocapillary hypercellularity, segmental sclerosis, tubular atrophy or interstitial fibrosis, and crescents. The T lesion drives most of the prognostic weight. Use the iga mest-c score result to inform your calculation.