What is the standard imatinib dose for CML chronic phase?

Adult CML chronic phase: 400 mg/day with food. Accelerated phase or blast crisis: 600 mg/day (some use 800 mg for blast crisis). Pediatric CML (weight-based): 340 mg/m²/day (max 400 mg). GIST adjuvant: 400 mg/day; metastatic: 400 mg/day (increase to 800 mg/day for primary KIT exon 9 mutations).

How is imatinib dose managed with hepatic impairment?

Imatinib is hepatically metabolized (CYP3A4). Mild hepatic impairment: 400 mg standard. Moderate hepatic impairment: no dose reduction but monitor liver function monthly. Severe hepatic impairment: reduce dose by 25% (300 mg/day). LFT elevation >5× ULN: hold imatinib, restart at 300 mg when resolved.

Imatinib Dose by Weight and Indication

Calculate imatinib dose for CML, GIST, and pediatric ALL by weight, indication, phase, and response milestones. Standard adult CML: 400 mg/day; accelerated phase/blast crisis: 600–800 mg/day.

Use the full interactive calculator below, or

Imatinib Dose by Weight and Indication

Frequently Asked Questions

What is the standard imatinib dose for CML chronic phase?

How is imatinib dose managed with hepatic impairment?