What AKI features predict CKD development?

CKD risk after AKI increases with: higher KDIGO stage (Stage 3: 30-40%), longer AKI duration, need for RRT, pre-existing CKD, diabetes, oliguria, and recurrent AKI episodes.

When should kidney function be re-evaluated after AKI?

KDIGO recommends follow-up kidney function assessment at 3 months after AKI. Patients with AKI Stage 2-3 or pre-existing CKD should have eGFR and UACR re-evaluated at 90 days.

What mechanisms drive AKI-to-CKD transition?

AKI-to-CKD: incomplete tubular repair, fibrosis from TGF-beta signaling, microvascular rarefaction, cell cycle arrest (G2/M), and persistent inflammation. RAAS blockade post-AKI may attenuate progression.

KDIGO AKI Staging to CKD Transition Risk

Estimate risk of AKI-to-CKD transition based on AKI severity, duration, and baseline kidney function. KDIGO stage 3 AKI carries 30-40% risk of new CKD at 3 months.

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KDIGO AKI Stage ATN vs Prerenal

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KDIGO AKI Staging to CKD Transition Risk

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Frequently Asked Questions

What AKI features predict CKD development?

When should kidney function be re-evaluated after AKI?

What mechanisms drive AKI-to-CKD transition?