Calculates lactate clearance rate and evaluates treatment response in sepsis. Formula: [(initial lactate − repeat lactate) / initial lactate] × 100%. Clearance ≥10% at 2 hours is associated with improved outcomes and similar mortality benefit to ScvO2 monitoring. Target lactate <2 mmol/L. Reassess every 2 hours in septic shock. Persistently elevated lactate indicates inadequate resuscitation or tissue hypoperfusion.
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