How is LEMS distinguished from myasthenia gravis clinically?

LEMS: proximal lower limb weakness (not ocular), autonomic features (dry mouth, erectile dysfunction, orthostasis), reduced reflexes that augment after brief exercise (post-tetanic facilitation). MG: ocular/bulbar predominant, no autonomic features, reflexes normal. VGCC-Ab positive in 85–90% of LEMS.

What is the DELTA-P score for predicting SCLC in LEMS?

DELTA-P: onset >50 years (1pt), weight loss >5 kg (1pt), smoking (1pt), bulbar symptoms negative (-1pt), erectile dysfunction/SOB (1pt), Karnofsky >70% (1pt). Score 0–1 = low SCLC risk; score ≥4 = 96% SCLC risk, requiring CT/PET staging urgently.

Lambert-Eaton Myasthenic Syndrome VGCC Probability

Estimate probability of Lambert-Eaton myasthenic syndrome and malignancy (SCLC) using clinical features, VGCC antibody titer, and DELTA-P paraneoplastic score.

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Lambert-Eaton Myasthenic Syndrome VGCC Probability

Frequently Asked Questions

How is LEMS distinguished from myasthenia gravis clinically?

What is the DELTA-P score for predicting SCLC in LEMS?