When is the Friedewald equation inaccurate?

Friedewald is inaccurate when TG >400 mg/dL. The Martin-Hopkins equation or direct LDL measurement is preferred in this case.

What is the optimal LDL level?

Optimal LDL is <100 mg/dL for most; <70 mg/dL for high-risk (established CVD); <55 mg/dL for very-high-risk patients.

High-intensity statins (atorvastatin 40-80mg, rosuvastatin 20-40mg) reduce LDL by ≥50%. Moderate-intensity reduces 30-50%.

Calculate LDL cholesterol using the Friedewald equation: LDL = Total Cholesterol - HDL - (Triglycerides/5).

Use the full interactive calculator below, or

ASCVD Risk

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Framingham Risk

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Non-HDL Cholesterol

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