What are the ISN/RPS lupus nephritis classes?

Class I: minimal mesangial. Class II: mesangial proliferative. Class III: focal ( =50% glomeruli, most severe). Class V: membranous. Class VI: advanced sclerosing (>90% globally sclerosed).

Which lupus nephritis class has worst prognosis?

Class IV (diffuse) has worst prognosis with highest risk of ESRD without aggressive therapy. Class III and class V have intermediate risk. Class II has excellent prognosis.

How does treatment differ by class?

Class III/IV: mycophenolate mofetil or cyclophosphamide induction + hydroxychloroquine + steroids. Class V: mycophenolate + RAAS blockade. Class VI: conservative CKD management and transplant evaluation.

Lupus Nephritis ISN/RPS Class Prognosis

Stage lupus nephritis by ISN/RPS 2018 classification (Class I-VI) and estimate renal prognosis and treatment intensity required per class.

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Lupus Nephritis ISN/RPS Class Prognosis

Frequently Asked Questions

What are the ISN/RPS lupus nephritis classes?

Which lupus nephritis class has worst prognosis?

How does treatment differ by class?