What are the ISN/RPS classes of lupus nephritis?

Class I: minimal mesangial. Class II: mesangial proliferative. Class III: focal (affecting = 50% glomeruli) - most severe. Class V: membranous. Class VI: advanced sclerosing (>= 90% globally sclerosed).

Which classes require aggressive immunosuppression?

Class III and IV require induction with high-dose steroids plus mycophenolate or cyclophosphamide, followed by maintenance therapy. Class IV has the worst prognosis without treatment.

What is the treatment for Class V lupus nephritis?

Class V (membranous): treatment depends on proteinuria severity. Nephrotic-range proteinuria: hydroxychloroquine plus immunosuppression (mycophenolate preferred). RAAS blockade for all.

Lupus Nephritis ISN/RPS Class Calculator

Classify lupus nephritis by ISN/RPS 2003 criteria: Class I-VI based on renal biopsy findings. Guides immunosuppressive treatment selection.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.

How It Works

Classify lupus nephritis by ISN/RPS 2003 criteria: Class I-VI based on renal biopsy findings. Guides immunosuppressive treatment selection

Each component has a specific meaning:

Renal biopsy findings — The renal biopsy findings recorded for the scenario being assessed.

Note: Interpret the lupus nephritis class result against the thresholds and context described above.

How to Use

Enter the renal biopsy findings for the scenario you are assessing. Classify lupus nephritis by ISN/RPS 2003 criteria: Class I-VI based on renal biopsy findings. Guides immunosuppressive treatment selection. Use the lupus nephritis class result to inform your calculation.

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