What are the ISN/RPS classes of lupus nephritis?

Class I: minimal mesangial. Class II: mesangial proliferative. Class III: focal (affecting = 50% glomeruli) - most severe. Class V: membranous. Class VI: advanced sclerosing (>= 90% globally sclerosed).

Which classes require aggressive immunosuppression?

Class III and IV require induction with high-dose steroids plus mycophenolate or cyclophosphamide, followed by maintenance therapy. Class IV has the worst prognosis without treatment.

What is the treatment for Class V lupus nephritis?

Class V (membranous): treatment depends on proteinuria severity. Nephrotic-range proteinuria: hydroxychloroquine plus immunosuppression (mycophenolate preferred). RAAS blockade for all.

Lupus Nephritis ISN/RPS Class Calculator

Classify lupus nephritis by ISN/RPS 2003 criteria: Class I-VI based on renal biopsy findings. Guides immunosuppressive treatment selection.

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