Is LVEF 50-54% considered reduced?

LVEF 50-54% is classified as mildly reduced (HFmrEF) per ESC 2021 guidelines. These patients share features of both HFpEF and HFrEF with intermediate prognosis.

What treatments apply to borderline LVEF?

Sacubitril/valsartan, beta-blockers, and SGLT2 inhibitors have emerging evidence in HFmrEF. Management should include guideline-directed therapy and monitoring for decline below 40%.

Do patients with LVEF 50-54% recover function?

A subset of HFmrEF patients improve to HFpEF (>=55%) or decline to HFrEF (<40%). Regular monitoring every 6-12 months is warranted to track EF trajectory.

LVEF 50-54% Borderline Significance

Assess the clinical significance of borderline reduced LVEF (50-54%), an intermediate zone between HFmrEF and HFpEF, with distinct prognosis and treatment implications.

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