Methotrexate Leucovorin Rescue Interval

Determine leucovorin rescue timing and dose after high-dose methotrexate (HDMTX) based on serum MTX levels at 24, 48, and 72 hours using standard rescue nomograms.

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Clinical Guidance

BMI is a screening measure of body size, not a direct measure of body fat. The standard WHO categories are underweight (<18.5), normal (18.5–24.9), overweight (25–29.9), and obese (≥30).

BMI can overestimate body fat in athletes with high muscle mass and underestimate it in older adults with low muscle mass. Interpret it alongside waist circumference and clinical context rather than as a standalone diagnosis.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.
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How It Works

Determine leucovorin rescue timing and dose after high-dose methotrexate (HDMTX) based on serum MTX levels at 24, 48, and 72 hours using standard rescue nomograms

Each component has a specific meaning:

  • Serum MTX levels at 24 — The serum mtx levels at 24 recorded for the scenario being assessed.
  • 48 — The 48 recorded for the scenario being assessed.
  • 72 hours — The 72 hours recorded for the scenario being assessed.

Note: Interpret the mtx leucovorin rescue result against the thresholds and context described above.

How to Use

Enter the serum MTX levels at 24, 48, 72 hours for the scenario you are assessing. Determine leucovorin rescue timing and dose after high-dose methotrexate (HDMTX) based on serum MTX levels at 24, 48, and 72 hours using standard rescue nomograms. Use the mtx leucovorin rescue result to inform your calculation.

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Frequently Asked Questions