What is the annual progression rate from MGUS to myeloma?

Overall progression rate is approximately 1% per year. Low-risk MGUS (IgG 1.5 g/dL, abnormal FLC ratio) has 20-year risk of 58%.

How often should MGUS be monitored?

Low-risk MGUS: repeat SPEP, CBC, and FLC at 6 months then every 2–3 years or if symptoms develop. High-risk MGUS: every 6 months for 2 years, then annually. Bone marrow biopsy is typically not required for low-risk MGUS at initial diagnosis.

MGUS Risk of Progression Per Year

Estimate annual and 20-year risk of MGUS progressing to myeloma or related disorder using the Mayo risk stratification model based on M-protein size, type, and FLC ratio.

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Frequently Asked Questions

What is the annual progression rate from MGUS to myeloma?

How often should MGUS be monitored?