What is the median OS for MIPI high-risk MCL?

High-risk MIPI (score above 6.2): median OS approximately 29 months in pre-BTKi era. Combined MIPI plus Ki-67 (combined MIPI-c) provides superior risk stratification; Ki-67 above 30% is the main driver of very poor outcomes requiring early stem cell transplant consideration.

How does ibrutinib impact MIPI risk stratification?

BTK inhibitors have dramatically improved outcomes in relapsed MCL but have not yet replaced upfront MIPI-based risk stratification. High-risk MIPI patients still have inferior outcomes with R-CHOP; intensive regimens (R-DHAP, R-CHOP alternating R-DHAP) followed by ASCT remain standard for fit patients.

MIPI Mantle Cell Lymphoma Prognosis

Calculate the Mantle Cell Lymphoma International Prognostic Index (MIPI) from age, ECOG performance status, LDH, and WBC count to classify low, intermediate, and high-risk disease.

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Frequently Asked Questions

What is the median OS for MIPI high-risk MCL?

How does ibrutinib impact MIPI risk stratification?