Nottingham Breast Cancer Grade

Calculate Nottingham histological grade (Grade 1-3) from three components scored 1-3 each: tubule formation, nuclear pleomorphism, and mitotic count per HPF. Total 3-5 = Grade 1; 6-7 = Grade 2; 8-9 = Grade 3.

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Clinical Guidance

BMI is a screening measure of body size, not a direct measure of body fat. The standard WHO categories are underweight (<18.5), normal (18.5–24.9), overweight (25–29.9), and obese (≥30).

BMI can overestimate body fat in athletes with high muscle mass and underestimate it in older adults with low muscle mass. Interpret it alongside waist circumference and clinical context rather than as a standalone diagnosis.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.
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How It Works

Calculate Nottingham histological grade (Grade 1-3) from three components scored 1-3 each: tubule formation, nuclear pleomorphism, and mitotic count per HPF. Total 3-5 = Grade 1; 6-7 = Grade 2; 8-9 = Grade 3

Each component has a specific meaning:

  • Nuclear pleomorphism — The nuclear pleomorphism recorded for the scenario being assessed.
  • Mitotic count per HPF — The mitotic count per hpf recorded for the scenario being assessed.

Note: Interpret the nottingham grade result against the thresholds and context described above.

How to Use

Enter the nuclear pleomorphism, mitotic count per HPF for the scenario you are assessing. Calculate Nottingham histological grade (Grade 1-3) from three components scored 1-3 each: tubule formation, nuclear pleomorphism, and mitotic count per HPF. Total 3-5 = Grade 1; 6-7 = Grade 2; 8-9 = Grade 3. Use the nottingham grade result to inform your calculation.

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