How has FEAST trial changed pediatric sepsis fluid recommendations?

The FEAST trial showed that saline boluses increased mortality in febrile African children with shock, leading WHO and some guidelines to recommend cautious, smaller boluses (10 mL/kg) with frequent reassessment rather than the previous 20 mL/kg aggressive push, particularly in resource-limited settings.

What are endpoints for pediatric fluid resuscitation?

Target normalization of heart rate for age, capillary refill under 2 seconds, normal blood pressure, improved mental status, and urine output greater than 1 mL/kg/hour. PICU admission if shock persists after 40–60 mL/kg within 1 hour.

Pediatric Fluid Resuscitation Sepsis Bolus

Calculate sepsis fluid resuscitation bolus for pediatric patients: 10–20 mL/kg isotonic crystalloid over 5–20 minutes, reassess after each bolus, titrate to perfusion endpoints per Surviving Sepsis guidelines.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.

How to Use

Enter the values for the scenario you are assessing. Calculate sepsis fluid resuscitation bolus for pediatric patients: 10–20 mL/kg isotonic crystalloid over 5–20 minutes, reassess after each bolus, titrate to perfusion endpoints per Surviving Sepsis guidelines. Use the pediatric sepsis fluid result to inform your calculation.

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